Luckily, melanotic macules are harmless. The oral melanotic macule (MM) is a small, well-circumscribed brown-to-black macule that occurs on the lips and mucous membranes. The exact cause of Melanotic Macules of Oral Mucosa is not well-understood. Lesions can also be found in the mouth (oral melanotic macule), on the vulva (vulval labial melanotic macule; vulval melanosis) or on the penis (penile melanotic macule). There are two major linked conditions. Conditions that are likely to cause macules are: vitiligo; moles; freckles See smartphone apps to check your skin. Excision can also be performed but will leave a scar. The color of the lesion is normally darker than the tissue that surrounds it. Melanotic macules are caused by functional hyperactivity of the regional melanocytes (ie, there is increased melanin production). It has also been found on the genital areas. Gupta G, Williams REA, Mackie RM. Intense pulsed light therapy which is a form of laser therapy. Having a melanotic macule does not cause any symptoms but when you see one it is usually smaller than seven millimeters in diameter. In the literature, the oral melanotic macule has been given various inappropriate and erroneous names, such as ephelis5,6 and lentigo7,8. Conclusion: The congenital lingual melanotic macule represents a clinically distinct, benign, pigmented oral melanoticlesion,andmaybemorecommonthanthelit-erature suggests. If you have any concerns with your skin or its treatment, see a dermatologist for advice. What causes an oral melanotic macule? Histologically, this is evidenced by abundant melanin pigmentation within the basal epithelial cell layer with melanin incontinence in … If it is irregular in shape or big it could be noticeable if removed. This lesion is completely benign, but biopsy must be performed to differentiate it from melanoma. As labial melanotic macules almost always occur on the central third of the lower lip, a site receiving maximum sun exposure, … Melanotic macules usually arise from three sources: an intraoral freckle, postinflammatory pigmentation, or disorders such as Addison’s disease, Peutz-Jeghers syndrome, or Laugier-Hunziker syndrome. What is the cause of labial melanotic macule? Home Lesions with a typical history and appearance need not be biopsied. GENETIC CAUSES. As most melanotic macule is benign for women they may be able to hide them under makeup if they are light in color and small enough so they do not attract any attention. Being born with one or having it appear in early childhood, which is common for people who have dark skin. Seventy‐nine patients presented to the pigmented lesion clinic between 1983 and 1996 with labial melanotic macules. Peutz-Jeghers syndrome– a genetic disorder with benign hamartomatous polyps in the GI tract, lips and oral mucosa 3. If a skin biopsy is done because the lesion is changing or looks irregular, a labial melanotic macule shows the following features on dermatopathology: Nuclear atypia is absent and the melanocyte count is normal. Their etiology is not clear and it may represent a physiologic or reactive process. H Arch Dermatol. In some people, if they opt to have it removed the tissue may heal well and leave little or no depression or scar. This medical condition is a dark spot that is usually found on your lips, usually the bottom one but can appear on the top lip also. Although most of the time they are solitary lesions there can be more than one. Author: Dr Mark Duffill, Dermatologist, Hamilton, New Zealand, 2008. It occurs in approximately three percent of the population of the world. Melanin pigmentation tends to be present in significant amounts in the basal-cell layer and less often in the lamina propria. [Sponsored content]. [1] Oral pigmented lesions result from cellular hyperplasia that can range from benign nevi to fatal oral melanoma. For most of the melanotic macule your dermatologist or physician will observe it over time to make sure that it does not change in shape, color, or texture and will not remove it and it will not need any treatment. However it may also occur in dark-skinned individuals and, as described above, similar lesions can arise in sites that are never sun-exposed. Once developed the lesions usually remain unchanged in size and colour. Some possible causes of Hypermelanotic macule or similar disorders may include: 4 Acute febrile neutrophilic dermatosis (Hypermelanotic macule) Amish infantile epilepsy syndrome (Hypermelanotic macule) Angioma serpiginosum, X-linked (Hypermelanotic macule) Oral pigmentation is a relatively common condition that may involve any portion of the oral cavity. Luckily, melanotic macules are harmless. When these macules occur in isolation, they are usually sporadic and no associated conditions are observed. There is a variety of causes for a person to have a melanotic macule. These are Genetic disorders and Lichen sclerosis. Labial melanotic macule (low power); mild acanthosis without elongation of rete ridges. NAME syndrome– a … Melanotic macules are benign pigmented lesions that are found in the oral cavity, caused by an increase in pigmentation in the basal cell layer of the epithelium and the lamina propria. [Congenital melanotic macules of the tongue] Last reviewed by Dr. Raj MD on August 14th, 2018. LEOPARD syndrome– a very rare inherited disorder with problems in the skin, face and heart 2. The melanosis may occur on the vermilion border of the lip or the gingiva due to postinflammatory or posttraumatic causes. A melanotic macule is a small dark spot that is usually benign, but may be a cause for concern if it changes in color, shape, or texture. Some of the rare genetic disorders associated with this condition include the following: 1. Who's at risk? Like skin freckles, the exact cause of an oral melanotic macule is unknown. It can even be found on the inside of your mouth, gums, called gingiva, the roof your mouth on the soft or hard palate, or inner cheek called buccal mucosa. Solar lentigo (high power) with increased basal layer pigmentation AND increased melanocyte numbers. When numerous macules are observed, they may be found in association with certain genetic conditions or syndromes. The exact cause for VM is unknown currently. The etiology is not clear and it may represent a physiologic or reactive process. Labial melanotic macule. The presence of numerous melanotic macules on the body may be associated with a variety of syndromes including Carney complex, Peutz-Jeghers syndrome, and LEOPARD syndrome. These spots usually appear on the lips or genitals and can have a number of causes. According to RDH Magazine, this common oral condition is present in 3 percent of the general population and is caused by a … Some of the possible causes of Hypermelanotic macule or similar disorders may include: 2. A variation of the melanotic macule is the ephelis, or freckle, which generally appears as a small (2- to 3-mm) brown spot on the lip. However, we know that it is due to over-production and accumulation of melanin within the tissues. Objective: Our purpose was to define the clinical, histologic, immunohistochemical, and electronmicroscopic features of genital melanotic macules. We have followed up these patients for up to 13 years and 3 months (mean 6 years, 3 months). Luckily, melanoma is very rare on the lip (but it can occur). Oral melanotic macules may have more of a predilection toward malignant melanoma than LMM. Oral melanotic macules can appear in people of any age, of any race, and of either sex. Melanotic macule may be indicative of preexisting disorders such as Addison’s disease; Treatment of melanotic macule. Size ranges from 1–8 mm. 7,8 The most common lesions are oral and labial melanotic macules. Multiple causes are known, and they may range from simple iatrogenic mechanisms, such as implantation of dental amalgam, to complex medical disorders, such as Peutz-Jeghers syndrome. If a child has one it is usually because of their race. Brown macules on the lower lip are relatively common, especially in young adult women. The lesions will usually appear as a flat non-itchy rash on the lip with a color that is uniform and has a border that is well-defined. Note that this may not provide an exact translation in all languages, breadcrumbs Lichen sclerosis – a skin disease which is characterized by white patches while are usually thinner than normal skin Some linked genetic disorders may include: 1. An oral melanotic macule found on the lip is sometimes called a labial melanotic macule. The mucosal melanotic macule is a variant of simple lentigo that is located on mucosal surfaces, in particular the lower lip. We present evidence that this is a benign entity. Oral Melanotic Macule identifiable etiologic factor, the term oral melanotic macule has been suggested2. Figure 3. If the melanotic macule is removed it can create a small scar or depression in the tissue which may or may not be noticeable. A labial melanotic macule may be confused with another pigmented skin lesion. The average age of presentation is 43 years, with a female predilection. It is usually asymptomatic and does not cause any severe signs or symptoms. doi: 10.1016/j.tripleo.2011.02.040. 2003;139:767-770 YPERPIGMENTED lesions involving the oral mu-cosa have various patho-genetic causes. A response to environmental stress such as persistent exposure to the sun, smoking, or taking a medication that can cause your skin to darken or spot, called, It could be an indicator of an underlying medical condition like. Topics A–Z Occasionally the lesion can be on the upper lip. Clinically presentation of melanotic macules are typically a brown, black, blue or grey area that is well circumscribed, lesions are usually less than 10 mm in diameter but can be larger in some cases. Shen ZY, Liu W, Bao ZX, Zhou ZT, Wang LZ Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011 Jul;112(1):e21-5. Usually solitary, a labial melanotic macule is most commonly seen in adult women but it also occurs in males and in young people. A labial melanotic macule is thought to be provoked by sun exposure, and it is more common in fair-skinned people. Simple lentigo — Simple lentigines often appear during childhood as sharply circumscribed, round-to-oval, uniformly brown or … A dermatologist can evaluate a melanotic macule to determine if it poses any health risks to the patient. Hence, treatment is not required. Oral melanotic macules do not cause an increase in the number of melanocytes and are not associated with a predisposition to melanoma. A labial melanotic macule is a well-defined, oval, brown to black, flat patch on the central third of the lower lip. Labial melanotic macule — codes and concepts. Clinical and dermatoscopic features of labial melanotic macule. Genetic disorders 2. Excision but using this form of removal will leave you a scar. Multiple lentiginosis (various syndromes including. Their occurrence, usually as new pigmented lesions in adult life, can cause concern because they can mimic early melanoma. The most common lesions are oral 1,2 The oral melanotic macule presents in patients older than 40 years as a flat, blue, brown, or black, mostly solitary lesion less than 10 mm in diameter. If treatment is requested the macules can be frozen (cryotherapy) or removed using a laser or intense pulsed light. Background: Genital melanotic macules are poorly recognized lesions, which appear as isolated discrete macules. Congenital lingual melanotic macules represent a clinically distinct and benign cause of hyperpigmentation of the oral mucosa. Melanin is a normal skin pigment that gives the skin its darker color. HYPERPIGMENTED lesions involving the oral mucosa have various pathogenetic causes. On the penis in men (penile melanotic macule, a penile lentigo). To make sure what type of treatment is needed, if any, they will usually do a skin biopsy to confirm if it is melanotic macule or another medical condition that could be precancerous or cancerous. DermNet provides Google Translate, a free machine translation service. Diagnosis confirmation. Macules can be caused by various conditions that affect the appearance of your skin, resulting in areas of discoloration. Multiple lesions may be a sign of a widespread skin condition, such as: A labial melanotic macule has a characteristic pattern when examined with the magnifying glass or by dermoscopy. DermNet NZ does not provide an online consultation service. Labial melanotic macule causes Labial melanotic macule is thought to be provoked by sun exposure, and it is more common in fair skinned people. If a person decides that they do want them removed this can be done by: Pictures collection of the condition Melanotic Macule…, 35 Most Frequently Asked Questions About Coronavirus (COVID-19) – (with references). British Journal of Dermatology 19997:136: 772-775. Ephelis (freckle) is a circumscribed brown macule over skin that has been exposed to sunlight. Oral melanotic macule is a non-cancerous (benign), dark spot found on the lips or inside the mouth. If you have any concerns with your skin or its treatment, see a dermatologist for advice. Melanotic macule is a harmless benign condition. Mucosal melanotic macule is a broader term encompassing lesions of the mouth as well as the lip. Suspicious lesions, including lesions showing progressive change, should be biopsied. Some of those causes can include: Being born with one or having it appear in early childhood, which is common for people who have dark skin. These conditions can be differentiated from labial melanotic macule by a combination of clinical and histological features. It is suggested that the term oral melanotic macule be used for these lesions, unless a specific cause can be confirmed by clinical data. DermNet NZ does not provide an online consultation service. Typical lesions can just be observed. With your help, we can update and expand the website. Local irritants, such as smoking, may also result in melanosis of varying degrees. Similar freckles may also occur in areas that are not exposed to the sun: Labial melanotic macules do not cause any symptoms but their appearance can be a concern to the patient. However it may also occur in dark-skinned individuals and, as described above, similar lesions can arise in sites that are never sun-exposed. Labial melanotic macules are differentiated from other entities by a combination of clinical and histologic features. They may be more common than the literature suggests, especially among dark-skinned subjects. Contact us to sponsor a DermNet newsletter. But before we proceed, we have to acknowledge that this condition is not related to systemic diseases or sunlight. » Oral melanotic macule and primary oral malignant melanoma: epidemiology, location involved, and clinical implications. It is also sometimes called a labial lentigo and when multiple lesions are present, mucosal melanosis. A melanotic macule is normally benign, which means it is not cancerous. A labial melanotic macule is thought to be provoked by sun exposure, and it is more common in fair-skinned people. Another name for this medical condition is labial melanotic macule and it is sometimes referred to as a freckle on the lip. They can occasionally have an irregular edge and there may be a history of colour change which can cause confusion with other pigmented lesions, including melanoma. The labial melanotic macule: a review of 79 cases. A mucosal melanocytic macule is a well-defined, oval, brown to black, flat patch, usually found on the lip (a labial melanocytic macule). Causes List for Hypermelanotic macule. Oral melanotic macule (MM) is a small, well-circumscribed, brown-to-black macule, and about of 665 cases has been reported in the English literature (2). A number of inherited diseases are manifested by pigmented oral lesions. Sponsored content: melanomas are notoriously difficult to discover and diagnose. It is the name for a freckle arising on the lip. This dark area could be a melanotic macule, which is a noncancerous dark patch on the skin — called hyperpigmentation — of a mucous membrane. Although it can appear at any age in either sex, race, or gender, it is most commonly found in people who are dark skinned and in their middle ages and are female. A melanotic macule is a benign pigmented lesion of oral cavity characterised by increase in melanin pigmentation. Some of those causes can include: If the melanotic macule begins to change in texture, color, or shape it may be a cause for concern and should be check by either your physician or dermatologist. It may also arise on the gingival, buccal, or palatal mucosa. Oral melanoacanthoma and oral melanotic macule: a report of 8 cases, review of the literature, and immunohistochemical analysis Román Carlos-Bregni 1 , Elisa Contreras 1 , Ana Carolina Netto , Adalberto Mosqueda-Taylor 2 , Pablo Agustin Vargas 3 , Jacks In such cases, the cause of the condition is genetically-influenced Currently, there is no specific cause for this vulvar benign but there are some rarely linked factors. » 6 Biopsy for routine histopathologic examination is recommended to rule out oral melanoma in patients with melanotic macule on the palate, where malignant melanoma is most prevalent. There are no outstanding histologic differences among the eighty specimens. Melanotic Macule Causes There is a variety of causes for a person to have a melanotic macule. There are two major related factors, including: 1. Usually sporadic and no associated conditions are observed pigmentation is a variety causes... Oral lesions in men ( penile melanotic macule is removed it can occur.... 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